Epinephrine

Mechanism of Action: Strong alpha-adrenergic effects, which cause an increase in cardio output and HR, a decrease in renal perfusion and PVR, and a variable effect on BP, resulting in systemic vasoconstriction and increased vascular permeability

Strong beta1- and moderate beta2-adrenergic effects, resulting in bronchial smooth muscle relaxation. Secondary relaxation effect on smooth muscle of stomach, intestine, uterus, and urinary bladder

Classification; bronchodilator nonselective adrenergic agonist, vasopressor

Used:

  • Asthma
  • Anaphylactic shock
  • Glaucoma
  • Cardiac arrest
  • Anesthetics

Contraindications: hypersensitivity to sympathomimetics, sulfites, closed-angle glaucoma, non anaphylactic shock during general anesthesia

Side effects: anxiety, insomnia, palpitations, tachycardia, hypertension, dysrhythmias, increased T wave, anorexia, sweating, dry eyes, dyspnea, paradoxical bronchospasm (inhalation), hypoglycemia

Controlled: High-Alert

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