Mechanism of action: Aspirin is a more potent inhibitor of both prostaglandin synthesis and platelet aggregation than its other salicylic derivatives due to the acetyl group on the aspirin molecule, which irreversibly inactivates cyclooxygenase via acetylation.
This prevents the conversion of arachidonic acid to thromboxane A. Platelet aggregation is inhibited for their lifespan of 7 to 10 days.
Therapeutic Class: non-opioid analgesic, non-steroidal anti-inflammatory, antipyretic, antiplatelet
Contraindications: hepatic disease, renal disease, alcoholism, chronic malnutrition, severe hypovolemia
Side Effects; anxiety, headache, dyspnea, hypertension or hypotension, hepatotoxicity, constipation, nausea, vomiting, renal failure (high doses/chronic use), neutropenia, muscle spasms, acute generalized exanthematous pustulosis, stevens- Johnson syndrome, toxic epidermal necrolysis, rash, urticaria